What are the Endometrial Cancer Causes?
Endometrial Cancer:
What are the Endometrial Cancer Causes?
Progesterone “opposes” estrogen your progesterone level goes up then drops at the end of each menstrual cycle, making the thick endometrium layer shed away. This is what you know as menstrual bleeding.
1. breast cancer
2.pelvic radiation therapy
3.high intake of animal fat[citation needed]
4.Tamoxifen
5.diabetes
6.endometrial polyps or other benign growths of the uterine
lining
7.late menopause
8.early menarche
9.infertility
10. nulliparity
Endometrial cancer is a cancer affecting the uterus. Research tells us the estrogen plays a large role in the development of endometrial cancer. In fact, most risk factors of endometrial cancer are estrogen related.The endometrium gets thicker and thicker. Over time, the endometrium cells can become cancerous.
Many of these cases are associated with hereditary non polyposis colorectal cancer , a dominantly inherited syndrome with germline mutations in one of the DNA-mismatch repair genes that can lead to microsatellite instability . HNPCC is characterized by early development of cancer in the colon as well as in the endometrium, stomach, small intestine and ovary.
Women with HNPCC have a tenfold higher lifetime risk of endometrial cancer compared with the general population, and that risk is even higher than that for colorectal carcinoma. Hereditary endometrial cancer is more likely to occur at a younger age than the sporadic form. Also, it is characterized by a high stage and grade, cribriform growth pattern, mucinous differentiation and necrosis
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