ehealthyland.com

Health:

Diabetes – What are Type 2 Diabetes Causes In Children? | Type 2 Diabetes Causes In Children | Causes Type 2 Diabetes In Children

The liver acts as a glucose storage and manufacturing center. When your child’s insulin levels are low when your child hasn’t eaten in a while, for example the liver releases the stored glucose to keep your child’s glucose level within a normal range.In type 2 diabetes, this process works improperly. Instead of moving into your child’s cells, sugar builds up in his or her bloodstream. This occurs when your child’s pancreas doesn’t make enough insulin or your child’s cells become resistant to the action of insulinGlucose sugar is a main source of energy for the cells that make up muscles and other tissues.

Glucose comes from two major sources the food your child eats and your child’s liver. During digestion, sugar is absorbed into the bloodstream. Normally, sugar then enters cells with the help of insulin.The exact cause of type 2 diabetes is not known. But experts believe the disease develops in children the same way it does in adults: the body does not produce enough of the hormone insulin, or it cannot correctly use the insulin available. Either or both of these conditions lead to excess sugar in the blood.Insulin resistance occurs when the body’s cells do not correctly use insulin, which helps control the amount of glucose in the blood.

The body then needs more insulin to control blood sugar levels.The pancreas produces more insulin to try to keep blood sugar levels normal. If it cannot produce enough insulin, blood sugar rises, and diabetes may develop.No one knows for sure what causes type 2 diabetes. Normally, when blood glucose level increases, the pancreas makes insulin to lower blood glucose levels. In type 2 diabetes, your child may have insulin resistance. In insulin resistance, your child’s pancreas keeps making insulin but his body cannot use the insulin correctly. The pancreas keeps making insulin to try to control your child’s blood sugar. After many years, your child’s pancreas may just stop working and stop making insulin. When this happens, sugar will build up in his blood.

Deletion of the gene for insulin receptor substrate 1 in mice, a molecule that promotes insulin uptake in skeletal muscle, resulted in only a small incidence of diabetes, because the beta cells were largely able to compensate for the defect by secreting additional insulin. This finding is compatible with human observational studies, in which people at risk for type 2 diabetes are generally no more insulin resistant than the vast majority of the obese population who do not develop diabetes. However, deletion of the both IRS 1 and IRS 2, a molecule that is necessary for both insulin secretion and insulin action, resulted in a significant increase in the incidence of diabetes in mice.These results suggest that both insulin resistance and a secretory defect of insulin are necessary for developing type 2 diabetes.

The prevalence of type 2 diabetes in children ranges from 4.1 per 1000 12 to 19 year olds in the US to 50.9 per 1000 15 to 19 year old Pima Indians of Arizona. 1 2 Between 8% and 45% of recently diagnosed cases of diabetes among children and adolescents in the United States is type 2, and the magnitude of this disease may be underestimated. The prevalence of the disease is on the rise in North America, and its incidence almost doubled in Japan between 1976 to 80 and 1991 to 1995 from 7.3 to 13.9 per 100 000 junior high school children. These trends coincide with the rising prevalence of overweight.

Incoming search terms:

• pima indian type 2 diabetes children